A prospective clinical trial of soygerm isoflavone extract reducing menopausal symptoms in menopausal women

By Ye Yan-bin et al, Sun Yat-sen University, Guangzhou, China, 2003

Hot flashes, sweating, headaches and insomnia commonly occur in perimenopausal women as a result of estrogen deficiency. Hormone replacement therapy (HRT) has shown efficacy in reducing these symptoms, but possible contraindications and undesirable side effects lead many women to search for alternatives. In this study, soy isoflavones from SoyLife EXTRA were investigated as an alternative to HRT for menopausal women.

Study design

In a single blind study, 87 early-menopausal women were randomly assigned to a daily treatment of 84 mg or 126 mg isoflavones (as aglycones) or a placebo. As a positive control, 10 women were treated daily with 2.5 mg estrogen. The estrogen group suffered from more severe menopausal complaints and were seeking help at the hospital.

During the 24-week study period, subjects recorded their hot flash frequency every fourth week. In addition, the Kuppermann index was used to score the severity of a more complete set of menopausal complaints. Each complaint was recorded in a validated questionnaire, scored individually, and multiplied by its rate of importance. The sum of these scores presents an estimation of overall suffering from menopause”. Serum concentrations of 17ß-estradiol (E2)